​*は責任著者(この研究室が主導で行ったもの）

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2026年

1. Matsuura, H., Hiraiwa, E., Deguchi, K., Ushiroda, C., Yamamoto-Wada, R., & Iizuka, K*. (2026). Household composition may modify the association between home cooking and dietary diversity among Japanese corporate employees. Nutrients. Advance online publication. 

2. Iizuka, K*., Hiraiwa, E., Matsuura, H., Yanagi, K., Kaito, K., Deguchi, K., & Naruse, H. (2026). Sex-dependent and asymmetric associations of bodyweight history in the twenties with later HbA1c trajectories in a Japanese occupational cohort. Nutrients, 18, 1532. https://doi.org/10.3390/nu18101532

3. Iizuka, K*., Matsuura, H., Yanagi, K., Hiraiwa, E., Sato, Y., Kaito, K., Yamamoto-Wada, R., Deguchi, K., & Naruse, H. (2026). Underweight in young adult women as a dynamic nutritional state: Evidence from four complementary longitudinal methods. Nutrients, 18, 1156. https://doi.org/10.3390/nu18071156

4. Kubota, S., Banno, S., Iizuka, K., Tsuchida, H., Kubota-Okamoto, S., Sakurai, T., Takahashi, Y., Imaizumi, T., Kato, T., Horikawa, Y., Tsunekawa, S., Usui, R., Tatsuoka, H., Tokumoto, S., Murakami, T., Fujiwara, Y., Kuwata, H., Yamazaki, Y., Yamada, Y., Seino, Y., & Yabe, D. (2026). ChREBP drives β-cell proliferation under metabolic stress but not in pregnancy-induced β-cell expansion. Journal of Diabetes Investigation. Advance online publication. https://doi.org/10.1111/jdi.70295

5. Iizuka, K*., Ito, A., Ushiroda, C., Hirano, K., Deguchi, K., Hiratsuka, I., Shibata, M., Takayanagi, T., Seino, Y., Sano, K., et al. (2026). An exploratory prospective intervention study on dietary content and HbA1c in experiential nutrition guidance for patients with type 2 diabetes. Nutrients, 18(6), 956. https://doi.org/10.3390/nu18060956

6. Kubota-Okamoto, S., Kubota, S., Tsuchida, H., Liu, Y., Banno, S., Imaizumi, T., Fujisawa, T., Takahashi, Y., Kato, T., Horikawa, Y., Iizuka, K., Murakami, T., Fujiwara, Y., Kuwata, H., Yamazaki, Y., Seino, Y., Tsunekawa, S., & Yabe, D. (2026). Endogenous GIP signaling is indispensable for DPP-4 inhibitor-mediated metabolic control in mice. Journal of Diabetes Investigation. Advance online publication. https://doi.org/10.1111/jdi.70252 

7. Yamamoto-Wada, R., Yoshimoto, J., Kodaira, Y., Deguchi, K., Aoki, Y., Kishi, M., & Iizuka, K*. (2026). Inverse associations of acetic acid intake with carbohydrate, sugar, and saturated fat intake: A multivariable analysis adjusted for age, sex, and energy intake in Japanese adults. Nutrients, 18, 318. 

8. Ito, M., Deguchi, K., Kaito, K., Yamamoto-Wada, R., Ushiroda, C., Naruse, H., & Iizuka, K*.  (2026). Exploratory study of soft drink intake, diet, and body size among employees at a Japanese university aged 20–39. Nutrients, 18, 292. 

9. Imaizumi, T., Iizuka, K*., Tsuchida, H., Sakai, M., Kubota, S., Kubota-Okamoto, S., Takahashi, Y., Takao, K., Kato, T., Mizuno, M., Hirota, T., Horikawa, Y., Tsunekawa, S., Murakami, T., & Yabe, D. (2026). ChREBP deficiency aggravates diabetic sarcopenia by disrupting glucose signaling: A novel mouse model of muscle atrophy. Journal of Endocrinology. Advance online publication. https://doi.org/10.1530/JOE-25-0257 ​​

2025年

1. Ushiroda, C., Ito, M., Yamamoto-Wada, R., Deguchi, K., Hidaka, S., Imaizumi, T., Seino, Y., Suzuki, A., Yabe, D., & Iizuka, K*. (2025). Insulin deficiency exacerbates muscle atrophy and osteopenia in Chrebp knockout mice. International Journal of Molecular Sciences, 26, 11672. https://doi.org/10.3390/ijms262311672

2. Yamamoto-Wada, R., Hiraiwa, E., Okuma, K., Yamada, M., Ushiroda, C., Deguchi, K., Naruse, H., Masuyama, H., & Iizuka, K*. (2025). Gut microbiota α- and β-diversity, but not dietary patterns, differ between underweight and normal-weight Japanese women aged 20–39 years. Nutrients, 17(20), 3265. 

3. Deguchi, K., Ikeda, K., Aoshima, M., Hiraiwa, E., Ono, C., Ushiroda, C., Yamamoto-Wada, R., & Iizuka, K*. (2025). High reproducibility and agreement of meal duration, number of chews, and chewing tempo measured with a standardized test meal. Nutrients, 17(15), 2438. 

4. Iizuka, K*., Yanagi, K., Deguchi, K., Ushiroda, C., Yamamoto-Wada, R., Ishihara, T., & Naruse, H. (2025). The alpha and beta diversities of dietary patterns differed by age and sex in young and middle-aged Japanese participants. Nutrients, 17(13), 2205. 

5. Hiraiwa, E., Yamamoto-Wada, R., Deguchi, K., Ushiroda, C., Naruse, H., & Iizuka, K*. (2025). The skeletal muscle mass index and body fat percentage differently reflect nutritional markers independently of BMI. Nutrients, 17(11), 1766. 

6. Deguchi, K., Aoshima, M., Hiraiwa, E., Ono, C., Ushiroda, C., Yamamoto-Wada, R., Yoshida, M., & Iizuka, K*.  (2025). The meal type rather than the meal sequence affects the meal duration, number of chews, and chewing tempo. Nutrients, 17, 1576. 

7. Ichikawa, R., Shibata, M., Nakura, Y., Iizuka, K., Uenishi, K., Sekiya, T., Suzuki, A., & Nishizawa, H. (2025). Inadequate calcium and vitamin D intake among Japanese women during the perinatal period: A cross-sectional study with bone health assessment. Nutrients, 17(6), 1075. 

8. Aoshima, M., Deguchi, K., Yamamoto-Wada, R., Ushiroda, C., Hiraiwa, E., Yokoi, M., Ono, C., Yoshida, M., & Iizuka, K*.  (2025). Greater numbers of chews and bites and slow external rhythmic stimulation prolong meal duration in healthy subjects. Nutrients, 17(6), 962. 

9. Deguchi, K., Ushiroda, C., Kamei, Y., Kondo, K., Tsuchida, H., Seino, Y., Yabe, D., Suzuki, A., Nagao, S., & Iizuka, K*. (2025). Glucose and insulin differently regulate gluconeogenesis and urea synthesis. Journal of Nutritional Science and Vitaminology, 71, 46–54. 

10. Deguchi, K., Ushiroda, C., Hidaka, S., Tsuchida, H., Yamamoto-Wada, R., Seino, Y., Suzuki, A., Yabe, D., & Iizuka, K*. (2025). Chrebp deletion and mild protein restriction additively decrease muscle and bone mass and function. Nutrients, 17(3), 488. 

2024年

1. Ushiroda, C., Deguchi, K., Yamamoto-Wada, R., Tanaka, H., Ono, C., Yoshida, M., Sarai, M., Miyahara, R., Sasaki, H., & Iizuka, K*. (2024). Oral antacid use is negatively associated with serum prealbumin levels in Japanese individuals undergoing health checkups. Nutrients, 16(21), 3715. https://doi.org/10.3390/nu16213715

2. Deguchi, K., Yoshimoto, J., Yamamoto-Wada, R., Ushiroda, C., Yanagi, K., Kishi, M., Naruse, H., & Iizuka, K*. (2024). Associations of acetate intake with protein and vitamin intake estimated via a food recording application. Nutrients, 16(7), 2977.

3. Iizuka, K*, Yanagi, K., Deguchi, K., Ushiroda, C., Yamamoto-Wada, R., Kobae, K., Yamada, Y., & Naruse, H. (2024). Sex and age differences in the effects of food frequency on blood parameters in Japanese adults. Nutrients, 16(7), 2931.

4. Nishida, K., Ueno, S., Seino, Y., Hidaka, S., Murao, N., Asano, Y., Fujisawa, H., Shibata, M., Takayanagi, T., Ohbayashi, K., Iwasaki, Y., Iizuka, K., Okuda, S., Tanaka, M., Fujii, T., Tochio, T., Yabe, D., Yamada, Y., Sugimura, Y., Hirooka, Y., Hayashi, Y., & Suzuki, A. (2024). Impaired fat absorption from intestinal tract in high-fat diet-fed male mice deficient in proglucagon-derived peptides. Nutrients, 16(14), 2270. https://doi.org/10.3390/nu16142270

5. Iizuka, K*, Deguchi, K., Ushiroda, C., Yanagi, K., Seino, Y., Suzuki, A., Yabe, D., Sasaki, H., Sasaki, S., Saitoh, E., & Naruse, H. (2024). A study on the compatibility of a food-recording application with questionnaire-based methods in healthy Japanese individuals. Nutrients, 16(11), 1742. https://doi.org/10.3390/nu16111742

6. Iizuka, K*, Kobae, K., Yanagi, K., Yamada, Y., Deguchi, K., Ushiroda, C., Seino, Y., Suzuki, A., Saitoh, E., & Naruse, H. (2024). Differing effects of body size on circulating lipid concentrations and hemoglobin A1c levels in young and middle-aged Japanese women. Healthcare, 12(4), 465. https://doi.org/10.3390/healthcare12040465

2023年

1. Iizuka, K* & Deguchi, K. (2023). Editorial: Diabetic renal tubulointerstitial disease. Frontiers in Endocrinology, 14, 1303514. https://doi.org/10.3389/fendo.2023.1303514

2. Iizuka, K* & Yabe, D. (2023). Dietary and nutritional guidelines for people with diabetes. Nutrients, 15(20), 4314. https://doi.org/10.3390/nu15204314

3. Ueno, S., Seino, Y., Hidaka, S., Nakatani, M., Hitachi, K., Murao, N., Maeda, Y., Fujisawa, H., Shibata, M., Takayanagi, T., Iizuka, K., Yabe, D., Sugimura, Y., Tsuchida, K., & Hayashi, Y. (2023). Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon-derived peptides. Journal of Diabetes Investigation. Advance online publication. https://doi.org/10.1111/jdi.14032

4. Iizuka, K*, Sato, H., Kobae, K., Yanagi, K., Yamada, Y., Ushiroda, C., Hirano, K., Ichimaru, S., Seino, Y., Ito, A., Suzuki, A., Saito, E., & Naruse, H. (2023). Young Japanese underweight women with “Cinderella weight” are prone to malnutrition, including vitamin deficiencies. Nutrients, 15(9), 2216. https://doi.org/10.3390/nu15092216

5. Iizuka, K*. (2023). Recent progress on fructose metabolism—ChREBP, fructolysis, and polyol pathway. Nutrients, 15(7), 1778. https://doi.org/10.3390/nu15071778

6. Iizuka, K*, Yabe, D., Abu-Farha, M., Abubaker, J., & Al-Mulla, F. (2023). Editorial: Advances in the research of diabetic nephropathy, volume II. Frontiers in Endocrinology, 14, 1135265. https://doi.org/10.3389/fendo.2023.1135265

7. Abu-Farha, M., Iizuka, K*, Yabe, D., Al-Mulla, F., & Abubaker, J. (2023). Editorial: Advances in the research of diabetic nephropathy. Frontiers in Endocrinology, 13, 1116188. https://doi.org/10.3389/fendo.2022.1116188

2022年

1. Iizuka, K*. (2022). Is the use of artificial sweeteners beneficial for patients with diabetes mellitus? The advantages and disadvantages of artificial sweeteners. Nutrients, 14(21), 4446. https://doi.org/10.3390/nu14214446

2. Iizuka, K*. (2022). Commentary: Comprehensive lipidome profiling of the kidney in early-stage diabetic nephropathy. Frontiers in Endocrinology, 13, 1015305. https://doi.org/10.3389/fendo.2022.1015305

3. Iizuka, K*., Ishihara, T., Watanabe, M., Ito, A., Sarai, M., Miyahara, R., Suzuki, A., Saitoh, E., & Sasaki, H. (2022). Nutritional assessment of hospital meals by food-recording applications. Nutrients, 14(18), 3754.

4. Sumida, A., Iizuka, K*., Kato, T., Liu, Y., Kubota, S., Kubota-Okamoto, S., Sakurai, T., Imaizumi, T., Takahashi, Y., Mizuno, M., Takao, K., Hirota, T., Suwa, T., Horikawa, Y., Yamamoto, M., Seino, Y., Suzuki, A., & Yabe, D. (2022). A case of familial hypocalciuric hypercalcemia type 1 due to CASR p.Pro55Leu mutation. BMC Endocrine Disorders, 22(1), 164. https://doi.org/10.1186/s12902-022-01077-5

5. Tsukada, D., Iizuka, K*., Takao, K., Liu, Y., Kubota, S., Okamoto-Kubota, S., Sakurai, T., Imaizumi, T., Sakai, M., Kato, T., Mizuno, M., Hirota, T., Suwa, T., Horikawa,Y., Yamamoto, M., Kubota, S., & Yabe, D. (2022). A case of Graves’ disease with thymic hyperplasia: Response of thyroid function, thyrotropin receptor autoantibody, and thymic size to thiamazole treatment. Internal Medicine, 61(18), 2753–2757.

6. Nomura, N., Iizuka, K*., Goshima, E., Hosomichi, K., Tajima, A., Kubota, S., Liu, Y., Takao, K., Kato, T., Mizuno, M., Hirota, T., Horikawa, Y., & Yabe, D. (2022). Glucokinase-maturity onset diabetes mellitus in the young suggested by factory-calibrated glucose monitoring data: A case report. Endocrine Journal, 69(4), 473–477.

2021年

1. 39.    Iizuka, K*. (2021). The roles of carbohydrate response element binding protein in the relationship between carbohydrate intake and diseases. International Journal of Molecular Sciences, 22(21), 12058.

2. 40.    Iizuka, K*. (2021). Protein amount, quality, and physical activity. Nutrients, 13(11), 3720.

3. 41.    Iizuka, K*, Baxter, M., Watanabe, D., & Yabe, D. (2021). Benefit of insulin glargine/lixisenatide for reducing residual hyperglycaemia in Japan: Post-hoc analysis of the LixiLan JP-O2 trial. Diabetes, Obesity and Metabolism, 23, 2795–2803.

4. 42.    Seino, Y., Iizuka, K., & Suzuki, A. (2021). Eating whole fruits, not drinking fruit juice, may reduce the risk of type 2 diabetes mellitus. Journal of Diabetes Investigation, 10, 1759–1761.

5. 43.    Tominari, S., Yasuda, M., Kato, T., Sakai, M., Kubota, S., Nonomura, K., Hirose, T., Takao, K., Liu, Y., Mizuno, M., Hirota, T., Iizuka, K., Suwa, T., Horikawa, Y., & Yabe, D. (2021). Hypoglycemic coma in an elderly adult switched from twice-daily vildagliptin to once-daily glimepiride to improve drug adherence. Diabetology International, 13(1), 295–299.

6. 44.    Yabe, D., Iizuka, K., Baxter, M., Watanabe, D., & Kaneto, H. (2021). iGlarLixi reduces residual hyperglycemia in Japanese patients with type 2 diabetes uncontrolled on basal insulin: A post-hoc analysis of the LixiLan JP-L trial. Journal of Diabetes Investigation, 12, 1992–2001.

7. 45.    Imaki, S., Iizuka, K*., Horikawa, Y., Yasuda, M., Kubota, S., Kato, T., Liu, Y., Takao, K., Mizuno, M., Hirota, T., Suwa, T., Hosomichi, K., Tajima, A., Fujiwara, Y., Yamazaki, Y., Kuwata, H., Seino, Y., & Yabe, D. (2021). A novel RFX6 heterozygous mutation (p.R652X) in maturity-onset diabetes mellitus: A case report. Journal of Diabetes Investigation, 12, 1914–1918.

8. 46.    Takao, K., Iizuka, K*., Liu, Y., Sakurai, T., Kubota, S., Kubota-Okamoto, S., Imaizumi, T., Takahashi, Y., Rakhat, Y., Komori, S., Hirose, T., Nonomura, K., Kato, T., Mizuno, M., Suwa, T., Horikawa, Y., Sone, M., & Yabe, D. (2021). Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis. Journal of Endocrinology, 248, 317–324.

9. 47.    Takao, K., Tani, A., Suwa, T., Kuwabara, Y., Nonomura, K., Liu, Y., Kato, T., Mizuno, M., Hirota, T., Enya, M., Iizuka, K., Horikawa, Y., Saigo, C., Kito, Y., Miyazaki, T., Ohe, N., Iwama, T., & Yabe, D. (2021). Diagnosis and treatment of primary central nervous system lymphoma with the primary lesion in the hypothalamus: A case report. BMC Endocrine Disorders, 21, 13.